Capecitabine-Induced Hyperosmolar Hyperglycemic State
نویسندگان
چکیده
Abstract Capecitabine is an orally administered prodrug of 5-fluorouracil (5-FU) which often used for treatment solid tumour cancers such as breast cancer and gastrointestinal tumours. Common adverse effects include nausea, diarrhea, anorexia erythrodysthesia (hand-foot syndrome). However, there have been case reports metabolic disturbances linked to capecitabine including hyperlipidemia, less commonly, hyperglycemia. We report a new diagnosis persistent diabetes mellitus following acute presentation hyperosmolar hyperglycemic syndrome (HHS) subsequent with the chemotherapy agent, capecitabine. A 72 year old female history metastatic was admitted hospital management state after bloodwork from her family doctor revealed elevated random blood glucose (40.2 mmol/L). Leading up presentation, patient had completed 7 cycles cancer. Prior treatment, did not mellitus. on admission, hemoglobin A1C (HbA1C) found into diabetic range. Offending medications were considered given temporal dysglycemia patient’s regimen, thought be probable offending agent. The acutely treated HHS, eventually transitioned basal-bolus insulin regimen at discharge. Her held pending review oncology team she closely followed by doctor. ultimately titrated down basal only. Given increasing use therapy in cancer, it important recognize risk hyperglycemia emergencies potential effect this treatment. It highlights need ensure that monitored throughout prevent emergencies.
منابع مشابه
Hyperosmolar Hyperglycemic State.
Hyperosmolar hyperglycemic state is a life-threatening emergency manifested by marked elevation of blood glucose and hyperosmolarity with little or no ketosis. Although there are multiple precipitating causes, underlying infections are the most common. Other causes include certain medications, nonadherence to therapy, undiagnosed diabetes mellitus, substance abuse, and coexisting disease. In ch...
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Diabetic ketoacidosis (DKA) and hyperglycemic hyperosmolar nonketotic syndrome (HHNS) are life-threatening acute metabolic complications of diabetes mellitus. Although there are some important differences, the pathophysiology, the presenting clinical challenge, and the treatment of these metabolic derangements are similar. Each of these complications can be seen in type 1 or type 2 diabetes, al...
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(a) History: Most patients with diabetic ketoacidosis (DKA) or with hyperosmolar hyperglycemic state (HHS) will have a history of diabetes, and a history of altered insulin dose, infection, signifi cant medical “stress”. Antecedent symptoms of polyuria and polydipsia, lassitude, blurred vision, and mental status changes may predominate the clinical picture. With DKA, abdominal pain and tachypne...
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ژورنال
عنوان ژورنال: Journal of the Endocrine Society
سال: 2021
ISSN: ['2472-1972']
DOI: https://doi.org/10.1210/jendso/bvab048.754